Anchor In Hotel Share: AccommodationsHotel Anchor In Hotel Visit Website One South Street Hyannis, MA 02601 (508) 775-0357 (508) 775-1313 (fax) About Map About Distinctive Waterfront Hotel with classic Cape Cod views of Hyannis harbor. Walk to island ferries, harbor cruises, Main St. and waterfront restaurants. Newly decorated guest rooms. Fodors says ''Deli What's Nearby? Distance: 5 10 15 20 25 50 mi.